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NWL-117

Chemical Structure : NWL-117

CAS No.: 2267318-43-2

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NWL-117 (NWL117, NWL 117)

Catalog No.: PC-70208Not For Human Use, Lab Use Only.

NWL-117 is a potent, ​BBB penetrant Caspase-6 inhibitor with IC50 of 192 nM, also inhibits Caspase-4/8/9/10 with IC50 of 0.1-0.8 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NWL-117 is a potent, BBB penetrant Caspase-6 inhibitor with IC50 of 192 nM, also inhibits Caspase-4/8/9/10 with IC50 of 0.1-0.8 uM.
    NWL-117 shows weak activity against other Capase subutypes.
    NWL-117 inhibits Caspase-6 in Caspase-6-transfected HCT116 cells with IC50 of 4.82 uM.
    NWL-117 inhibits serum deprivation-induced Caspase-6 activity and prevents amyloid precursor protein-mediated neurite degeneration in human primary CNS neurons.

    Physicochemical Properties

    M.Wt 654.732
    Formula C29H42N4O11S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (5S,8S,11S,14R)-11-((S)-sec-butyl)-8-(2-carboxyethyl)-5-isopropyl-14-((E)-2-(methylsulfonyl)vinyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazapentadecan-15-oic acid

    References

    1. Pakavathkumar P, et al. Mol Neurodegener. 2017 Feb 28;12(1):22.

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