Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : NWL-117
Catalog No.: PC-70208Not For Human Use, Lab Use Only.
NWL-117 is a potent, BBB penetrant Caspase-6 inhibitor with IC50 of 192 nM, also inhibits Caspase-4/8/9/10 with IC50 of 0.1-0.8 uM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
NWL-117 is a potent, BBB penetrant Caspase-6 inhibitor with IC50 of 192 nM, also inhibits Caspase-4/8/9/10 with IC50 of 0.1-0.8 uM.
NWL-117 shows weak activity against other Capase subutypes.
NWL-117 inhibits Caspase-6 in Caspase-6-transfected HCT116 cells with IC50 of 4.82 uM.
NWL-117 inhibits serum deprivation-induced Caspase-6 activity and prevents amyloid precursor protein-mediated neurite degeneration in human primary CNS neurons.
| M.Wt | 654.732 | |
| Formula | C29H42N4O11S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Pakavathkumar P, et al. Mol Neurodegener. 2017 Feb 28;12(1):22.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
