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Chemical Structure : Nafamostat mesylate
CAS No.: 82956-11-4
Catalog No.: PC-47020Not For Human Use, Lab Use Only.
Nafamostat mesylate is a synthetic serine protease inhibitor with anticoagulant, anti-inflammatory, mucus clearing, and potential antiviral activities, blocked SARS-CoV-2 infection of Calu-3 cells with IC50 of 10 nM.
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Nafamostat mesylate is a synthetic serine protease inhibitor with anticoagulant, anti-inflammatory, mucus clearing, and potential antiviral activities, blocked SARS-CoV-2 infection of Calu-3 cells with IC50 of 10 nM.
Nafamostat mesylate potently inhibits SARS-CoV-2 S protein-mediated fusion in a cell fusion assay system and also inhibits SARS-CoV-2 infection in vitro in a cell-type-dependent manner.
| M.Wt | 539.6 | |
| Formula | C21H25N5O8S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester dimethanesulfonate |
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1. Hoffmann M, et al. Antimicrob Agents Chemother. 2020 May 21;64(6):e00754-20.
2. Zhou H, et al. Br J Pharmacol. 2020 Jul;177(14):3147-3161.
3. Yamamoto M, et al. Viruses. 2020 Jun 10;12(6):629.
4. Markus Hoffmann, et al. Cell. 2020 Apr 16;181(2):271-280.e8.
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