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Naphthyridine-azaquinolone

Chemical Structure : Naphthyridine-azaquinolone

CAS No.: 500722-22-5

Naphthyridine-azaquinolone

Catalog No.: PC-73136Not For Human Use, Lab Use Only.

Naphthyridine-azaquinolone (NA) is a specific small molecule that specifically binds slipped-CAG DNA intermediates of expansion mutations.

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    Biological Activity

    Naphthyridine-azaquinolone (NA) is a specific small molecule that specifically binds slipped-CAG DNA intermediates of expansion mutations.
    Naphthyridine-azaquinolone specifically inhibits repair of long CAG slip-outs by human (HeLa) cell extracts.
    Naphthyridine-azaquinolone modulates instability of expanded mutant repeats in Huntington's disease (HD) cells, with limited off-target effects.
    NA induces CAG contractions, independent of proliferation, dependent on rCAG transcription, affects interaction of DNA repair proteins on long CAG slip-outs.
    Naphthyridine-azaquinolone modulates repeat instability in the striatum of HD mice, induces a reduction in mHTT aggregates in R6/2 mice.
    Naphthyridine-azaquinolone-induced contractions depend upon active expansions driven by MutSβ.

    Physicochemical Properties

    M.Wt 459.51
    Formula C24H25N7O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    3-[[3-[(7-Methyl-1,8-naphthyridin-2-yl)amino]-3-oxopropyl]amino]-N-[(7-oxo-8H-1,8-naphthyridin-2-yl)methyl]propanamide

    References

    1. Nakamori M, et al. Nat Genet. 2020 Feb;52(2):146-159.

    2. Hasuike Y, et al. Neurobiol Dis. 2022 Feb;163:105604.

    3. Deshmukh AL, et al. Cell Rep. 2021 Dec 7;37(10):110078.

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