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Chemical Structure : Nateglinide
CAS No.: 105816-04-4
Catalog No.: PC-20822Not For Human Use, Lab Use Only.
Nateglinide (Senaglinide, DJN-608, A-4166) is an oral hypoglycaemic agent and non-sulphonylurea insulin secretagogue, also is a MRGPRX4 agonist.
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|---|---|---|---|
| 100 mg | $188 | In stock | |
| 200 mg | $288 | In stock | |
| 500 mg | $458 | In stock | |
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Nateglinide (Senaglinide, DJN-608, A-4166) is an oral hypoglycaemic agent and non-sulphonylurea insulin secretagogue and DPP IV inhibitor, also is a MRGPRX4 agonist.
Nateglinide (Senaglinide, DJN-608, A-4166) stimulated insulin secretion from rat freshly isolated pancreatic islets at concentrations from 3-300 uM in the presence of 2.8 uM glucose.
Nateglinide (Senaglinide, DJN-608, A-4166) displaced [3H]-glibenclamide bound to intact HIT-T15 cells in a concentration-dependent manner with Ki of 434 nM.
Nateglinide (Senaglinide, DJN-608, A-4166) (1-10 mg/kg, oral) showed a dose-dependent hypoglycaemic effect in fasted beagle dogs.
| M.Wt | 317.43 | |
| Formula | C19H27NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2R)-3-phenyl-2-[(4-propan-2-ylcyclohexanecarbonyl)amino]propanoic acid |
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1. Shinkai H, et al. J Med Chem. 1989 Jul;32(7):1436-41.
2. Ikenoue T, et al. Br J Pharmacol. 1997 Jan;120(1):137-45.
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