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Necrosis inhibitor IM-17

Chemical Structure : Necrosis inhibitor IM-17

CAS No.: 2213445-82-8

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Necrosis inhibitor IM-17

Catalog No.: PC-27001Not For Human Use, Lab Use Only.

IM-17 is a specific oxidative stress-induced necrosis inhibitor, inhibits necrotic cell death induced by H2O2 with IC50 of 1.0 uM in HL-60 cells, does not inhibit apoptosis induced by various anticancer drugs or Fas ligand, or necroptosis.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

IM-17 is a specific oxidative stress-induced necrosis inhibitor, inhibits necrotic cell death induced by H2O2 with IC50 of 1.0 uM in HL-60 cells, does not inhibit apoptosis induced by various anticancer drugs or Fas ligand, or necroptosis.
IM-17 has IC50 of 4.9 uM against H9c2 cells treated with TBHP.
IM-17 showscardioprotective effects in an isolated rat heart model and an in vivo arrhythmia model.

Physicochemical Properties

M.Wt 298.35
Formula C16H18N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-((2-aminoethyl)amino)-1-methyl-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

References

1. Dodo K, et al. ACS Med Chem Lett. 2018 Jan 29;9(3):182-187.

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