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Nedosiran Sodium

Chemical Structure : Nedosiran Sodium

CAS No.: 2247026-22-6

Nedosiran Sodium (DCR-PHXC sodium)

Catalog No.: PC-23051Not For Human Use, Lab Use Only.

Nedosiran sodium is a GalNAc-dsRNA conjugated RNA interference agent designed to inhibit production of the hepatic lactate dehydrogenase (LDH) enzyme, the enzyme responsible for the common, final step of oxalate production in all three genetic subtypes of primary hyperoxaluria (PH).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Nedosiran sodium is a GalNAc-dsRNA conjugated RNA interference agent designed to inhibit production of the hepatic lactate dehydrogenase (LDH) enzyme, the enzyme responsible for the common, final step of oxalate production in all three genetic subtypes of primary hyperoxaluria (PH).

Physicochemical Properties

M.Wt 22183.60
Formula
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

References

1. Hoppe B, et al. Kidney Int. 2022 Mar;101(3):626-634.

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