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Chemical Structure : Nek2 inhibitor (R)-21
Catalog No.: PC-61483Not For Human Use, Lab Use Only.
A potent and selective NIMA-related Kinase 2 (NEK2) inhibitor with IC50 of 22 nM, >200-fold selectivity over Plk1, Mps1, Aurora A and CDK2.
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Nek2 inhibitor (R)-21 is a potent and selective NIMA-related Kinase 2 (NEK2) inhibitor with IC50 of 22 nM, >200-fold selectivity over Plk1, Mps1, Aurora A and CDK2.
Nek2 inhibitor (R)-21 also shows >100-fold selectivity over a panel of 24 kinases.
Nek2 inhibitor (R)-21 down-regulates C-Nap1 phosphoryation with IC50 of 0.8 uM, shows antiproliferative effect on U2OS, MDA-MB-231, HeLa and MCF7 cell with GI50 of 1.82, 4.16, 0.59 and 2.17 uM, respectively.
Nek2 inhibitor (R)-21 is a valuable tool for investigating the role of Nek2 in the cell cycle and its function in mitotic organization.
| M.Wt | 490.545 | |
| Formula | C24H25F3N4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Innocenti P, et al. J Med Chem. 2012 Apr 12;55(7):3228-41.
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