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Chemical Structure : Nek2 inhibitor 3a
Catalog No.: PC-61478Not For Human Use, Lab Use Only.
Nek2 inhibitor 3a is a potent, relatively selective Nek2 inhibitor with IC50 of 82.74 nM in cell-free assays.
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Nek2 inhibitor 3a is a potent, relatively selective Nek2 inhibitor with IC50 of 82.74 nM in cell-free assays.
Nek2 inhibitor 3a inhibits only 3 kinases (YSK4, FLT3-ITDD835V and FLT3-ITDF691L) against 97 kinases with >65% inhibition at 15 nM.
Nek2 inhibitor 3a blocks NEK2-EZH2 complex formation and inhibits tumor cell proliferation.
Nek2 inhibitor 3a efficiently attenuates GBM growth in mouse model and exhibits a synergistic effect with radiotherapy.
| M.Wt | 568.619 | |
| Formula | C28H27F3N6O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang J, et al. J Clin Invest. 2017 Aug 1;127(8):3075-3089.
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