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Nek2 inhibitor 66

Chemical Structure : Nek2 inhibitor 66

CAS No.: 1507367-00-1

Nek2 inhibitor 66 (NCL-00017509)

Catalog No.: PC-20311Not For Human Use, Lab Use Only.

Nek2 inhibitor 66 (NCL-00017509) is a potent, selective and irreversible inhibitor of Nek2 with IC50 of 62 nM, exhibits growth inhibitory activity in the SKBR3 cell line with GI50 of 2.2 uM.

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Biological Activity

Nek2 inhibitor 66 (NCL-00017509) is a potent, selective and irreversible inhibitor of Nek2 with IC50 of 62 nM, exhibits growth inhibitory activity in the SKBR3 cell line with GI50 of 2.2 uM.
Nek2 inhibitor 66 (5-10 uM) reduced C-Nap1 phosphorylation in U2OS cells.

Physicochemical Properties

M.Wt 292.30
Formula C15H12N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(3-((6-ethynyl-9H-purin-2-yl)amino)phenyl)acetamide

References

1. Christopher J Matheson, et al. RSC Med Chem. 2020 May 22;11(6):707-731.

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