Nek2 inhibitor 66 (NCL-00017509)

Chemical Structure : Nek2 inhibitor 66

CAS No.: 1507367-00-1

Catalog No.: PC-20311Not For Human Use, Lab Use Only.

Nek2 inhibitor 66 (NCL-00017509) is a potent, selective and irreversible inhibitor of Nek2 with IC50 of 62 nM, exhibits growth inhibitory activity in the SKBR3 cell line with GI50 of 2.2 uM.

Packing	Price	Stock
1 mg	$188	In stock
5 mg	$358	In stock
10 mg	$548	In stock
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100 mg		Get quote

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Biological Activity

Nek2 inhibitor 66 (NCL-00017509) is a potent, selective and irreversible inhibitor of Nek2 with IC50 of 62 nM, exhibits growth inhibitory activity in the SKBR3 cell line with GI50 of 2.2 uM.
Nek2 inhibitor 66 (5-10 uM) reduced C-Nap1 phosphorylation in U2OS cells.

Physicochemical Properties

M.Wt	292.30
Formula	C15H12N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-((6-ethynyl-9H-purin-2-yl)amino)phenyl)acetamide

References

1. Christopher J Matheson, et al. RSC Med Chem. 2020 May 22;11(6):707-731.

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