Nek2 inhibitor Compound 53

Chemical Structure : Nek2 inhibitor Compound 53

Catalog No.: PC-27623Not For Human Use, Lab Use Only.

Nek2 inhibitor Compound 53 is a potent small molecule inhibitor of Nek2 with IC50 of 1.42 uM, >50-fold more potently than strong R-spine mutant Nek7SRS and Nek7WT.

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Biological Activity

Nek2 inhibitor Compound 53 is a potent small molecule inhibitor of Nek2 with IC50 of 1.42 uM, >50-fold more potently than strong R-spine mutant Nek7SRS and Nek7WT.

Physicochemical Properties

M.Wt	487.62
Formula	C23H33N7O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((6-(cyclohexylmethoxy)-9H-purin-2-yl)amino)-N-(3-(dimethylamino)propyl)benzenesulfonamide

References

1. Byrne MJ, et al. Biochem J. 2020 Apr 30;477(8):1525-1539.

2. Sood A. Mol Neurobiol. 2026 Aug 4;63(1):808.

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