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Nek2 inhibitor V8

Chemical Structure : Nek2 inhibitor V8

CAS No.: 1189421-14-4

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Nek2 inhibitor V8

Catalog No.: PC-20888Not For Human Use, Lab Use Only.

Nek2 inhibitor V8 is a novel spirocyclic selective, reversible inhibitor of NIMA Related Kinase 2 (Nek2) kinase with IC50 of 2.4 uM, attenuates pAkt/PI3K signaling.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Nek2 inhibitor V8 is a novel spirocyclic selective, reversible inhibitor of NIMA Related Kinase 2 (Nek2) kinase with IC50 of 2.4 uM, attenuates pAkt/PI3K signaling.
    Nek2 inhibitor V8 attenuates proliferative and migratory phenotypes of highly aggressive human MDA-MB-231 breast and A549 lung cancer cell lines.

    Physicochemical Properties

    M.Wt 386.26
    Formula C14H16BrN3O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(4-Bromophenyl)-8-(methylsulfonyl)-1,4,8-triazaspiro[4.5]dec-3-en-2-one

    References

    1. Bhuiyan AI, et al. Bioorg Med Chem Lett. 2023 May 15;88:129288.

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