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Nek2 inhibitor V8

Chemical Structure : Nek2 inhibitor V8

CAS No.:

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Nek2 inhibitor V8

Catalog No.: PC-20888Not For Human Use, Lab Use Only.

Nek2 inhibitor V8 is a novel spirocyclic selective, reversible inhibitor of NIMA Related Kinase 2 (Nek2) kinase with IC50 of 2.4 uM, attenuates pAkt/PI3K signaling.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Nek2 inhibitor V8 is a novel spirocyclic selective, reversible inhibitor of NIMA Related Kinase 2 (Nek2) kinase with IC50 of 2.4 uM, attenuates pAkt/PI3K signaling.
Nek2 inhibitor V8 attenuates proliferative and migratory phenotypes of highly aggressive human MDA-MB-231 breast and A549 lung cancer cell lines.

Physicochemical Properties

M.Wt 386.26
Formula C14H16BrN3O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C1NC2(CCN(S(=O)(C)=O)CC2)N=C1C3=CC=C(Br)C=C3

References

1. Bhuiyan AI, et al. Bioorg Med Chem Lett. 2023 May 15;88:129288.

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