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Nezulcitinib

Chemical Structure : Nezulcitinib

CAS No.: 2412496-23-0

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Nezulcitinib (TD-0903, TD0903)

Catalog No.: PC-38381Not For Human Use, Lab Use Only.

Nezulcitinib (TD-0903) is a inhaled lung-selective pan-JAK inhibitor, targets all JAK isoforms (JAK1, JAK2, JAK3, TYK2), Nezulcitinib is under development for treatment of acute lung injury associated with COVID-19.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Nezulcitinib (TD-0903) is a inhaled lung-selective pan-JAK inhibitor, targets all JAK isoforms (JAK1, JAK2, JAK3, TYK2), Nezulcitinib is under development for treatment of acute lung injury associated with COVID-19.

    Physicochemical Properties

    M.Wt 527.673
    Formula C30H37N7O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-(3-(dimethylamino)azetidin-1-yl)(2-(6-(2-ethyl-4-hydroxyphenyl)-1H-indazol-3-yl)-5-isopropyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-6-yl)methanone

    References

    1. Singh D, et al. Eur Respir J. 2021 Oct 14;58(4):2100673.

    2. Spinelli, F. R., Conti, F. & Gadina, M. HiJAKing SARS-CoV-2? The potential role of JAK inhibitors in the management of COVID-19. Sci. Immunol. 5, eabc5367 (2020).

    3. Pfeifer ND, et al. Clin Transl Sci. 2021 Nov;14(6):2556-2565.

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