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Nitisinone

Chemical Structure : Nitisinone

CAS No.: 104206-65-7

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Nitisinone (NTBC, Nitisone, SC0735)

Catalog No.: PC-21242Not For Human Use, Lab Use Only.

Nitisinone (NTBC, Nitisone, SC0735) is a potent, orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with IC50 of 173 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Nitisinone (NTBC, Nitisone, SC0735) is a potent, orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with IC50 of 173 nM.
Nitisinone (NTBC, Nitisone, SC0735) promotes tyrosine accumulation in a dose-dependent manner.
4-HPPD is a target for treating type I tyrosinemia and other diseases with defects in tyrosine catabolism.

Physicochemical Properties

M.Wt 329.23
Formula C14H10F3NO5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(2-nitro-4-(trifluoromethyl)benzoyl)cyclohexane-1,3-dione

References

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