Nitisinone | 4-HPPD inhibitor | Probechem Biochemicals

Chemical Structure : Nitisinone

CAS No.: 104206-65-7

Nitisinone (NTBC, Nitisone, SC0735)

Catalog No.: PC-21242Not For Human Use, Lab Use Only.

Nitisinone (NTBC, Nitisone, SC0735) is a potent, orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with IC50 of 173 nM.

Packing	Price	Stock
25 mg	$198	In stock
50 mg	$298	In stock
100 mg	$488	In stock
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Biological Activity

Nitisinone (NTBC, Nitisone, SC0735) is a potent, orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with IC50 of 173 nM.
Nitisinone (NTBC, Nitisone, SC0735) promotes tyrosine accumulation in a dose-dependent manner.
4-HPPD is a target for treating type I tyrosinemia and other diseases with defects in tyrosine catabolism.

Physicochemical Properties

M.Wt	329.23
Formula	C14H10F3NO5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-nitro-4-(trifluoromethyl)benzoyl)cyclohexane-1,3-dione

References

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Nitisinone (NTBC, Nitisone, SC0735)

Biological Activity

Physicochemical Properties

References

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