Catalog No.: PC-26191Not For Human Use, Lab Use Only.
Nitrosonisoldipine is a photodegradation product of calcium channel inhibitor nisoldipine, is a selective inhibitor of inflammatory caspases, inhibits noncanonical pyroptosis mediated by caspase-11 or caspase-4 and canonical pyroptosis mediated by caspase-1.
Nitrosonisoldipine is a photodegradation product of calcium channel inhibitor nisoldipine, is a selective inhibitor of inflammatory caspases, inhibits noncanonical pyroptosis mediated by caspase-11 or caspase-4 and canonical pyroptosis mediated by caspase-1. Nitrosonisoldipine inhibits noncanonical pyroptosis in iBMDMs。 Nitrosonisoldipine blocks caspase-4/-11 activation in noncanonical pyroptosis. Nitrosonisoldipine blocks caspase-1 activation in canonical pyroptosis. Nitrosonisoldipine does not affect apoptosis. Nitrosonisoldipine directly and irreversibly inhibits the enzyme activities of inflammatory caspases. Nitrosonisoldipine (4.44, 14.8, and 44.4 mg/kg) is protective in LPS- and polymicrobe-induced sepsis in C57BL/6 mice.
