Catalog No.: PC-63473Not For Human Use, Lab Use Only.
Nobiletin is an O-methylated flavone that has the activity to rescue bulbectomy-induced memory impairment, also is a clock modulator that targets RORα/γ.
Nobiletin is an O-methylated flavone that has the activity to rescue bulbectomy-induced memory impairment, also is a clock modulator that targets RORα/γ.
Nobiletin induces neurite outgrowth of PC12D cells, causes a concentration-dependent enhancement of Erk/MAP kinase phosphorylation and a sustained increment of phosphorylation of MEK and Erk/MAP kinase.
Nobiletin also preferentially inhibits Ca2+/CaM-dependent phosphodiesterase in vitro.
Nobiletin enhances the clock and concordantly renders protection against metabolic syndrome in a Clock gene-dependent manner, enhances RORα/γ transcriptional activity via direct binding to RORα/γ.
Physicochemical Properties
M.Wt
402.399
Formula
C21H22O8
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
3',4',5,6,7,8-Hexamethoxyflavone
References
1. Nagase H, et al. Biochemistry. 2005 Oct 25;44(42):13683-91.
2. He B, et al. Cell Metab. 2016 Apr 12;23(4):610-21.
3. Nakajima A, et al. J Pharmacol Sci. 2007 Sep;105(1):122-6.
