Nomelcitinib (D-2570) | Tyk2 inhibitor

Chemical Structure : Nomelcitinib

Catalog No.: PC-26345Not For Human Use, Lab Use Only.

Nomelcitinib (D-2570) is a potent, selective tyrosine kinase 2 (TYK2) inhibitor, selectively binds to the JH2 domain of TYK2.

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Biological Activity

Nomelcitinib (D-2570) is a potent, selective tyrosine kinase 2 (TYK2) inhibitor, selectively binds to the JH2 domain of TYK2.

M.Wt	427.88
Formula	C16H14D3ClN6O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Pyridazinecarboxamide, 4-[[5-chloro-3-(methylsulfonyl)-2-pyridinyl]amino]-6-[(cyclopropylcarbonyl)amino]-N-(methyl-d3)-

1. Patent WO2022135430 A1 2022-06-30.

2. Zhang J, et al. J Am Acad Dermatol. 2026 Jan;94(1):143-150.