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Nrf2 activator 16

Chemical Structure : Nrf2 activator 16

CAS No.: 321694-20-6

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Nrf2 activator 16 (Keap1-Nrf2 inhibitor 16)

Catalog No.: PC-62795Not For Human Use, Lab Use Only.

Nrf2 activator 16 is a potent Keap1-Nrf2 and Keap1-p-p62 protein-protein interaction inhibitor with IC50 of 0.91 uM and 1.8 uM respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Nrf2 activator 16 is a potent Keap1-Nrf2 and Keap1-p-p62 protein-protein interaction inhibitor with IC50 of 0.91 uM and 1.8 uM respectively.
    Nrf2 activator 16 upregulates Nrf2 response genes measured by a luciferase cell reporter assay.

    Physicochemical Properties

    M.Wt 498.568
    Formula C24H22N2O6S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N,N'-(naphthalene-1,4-diyl)bis(4-methoxybenzenesulfonamide)

    References

    1. Saito T, et al. Nat Commun. 2016 Jun 27;7:12030.

    2. Yasuda D, et al. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5956-5959.

    3. Marcotte D, et al. Bioorg Med Chem. 2013 Jul 15;21(14):4011-9.

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