Chemical Structure : Nutlin-3a
CAS No.:
675576-98-4
Nutlin-3a
(Rebemadlin)
Catalog No. : PC-42100Not For Human Use, Lab Use Only.
Nutlin-3a (Rebemadlin) is the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4210001
Biological Activity
Nutlin-3a (Rebemadlin) is the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay.
Physicochemical Properties
M.Wt
581.4896
Formula
C30H30Cl2N4O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-Piperazinone, 4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-
References
1. Vassilev LT, et al. Science
2. Schneider LS, et al. Mol Oncol
3. Tonsing-Carter E, et al. Mol Cancer Ther
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