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Chemical Structure : ODM-207
CAS No.: 1801503-93-4
Catalog No.: PC-38064Not For Human Use, Lab Use Only.
ODM-207 (ODM207) is a highly potent, selective and orally active pan-BET inhibitor with potent and broad antiproliferative effects.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $228 | In stock | |
| 25 mg | $428 | In stock | |
| 100 mg | $988 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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ODM-207 (ODM207) is a highly potent, selective and orally active pan-BET inhibitor with potent and broad antiproliferative effects.
ODM-207 effectively inhibits the proliferation of ER+ breast cancer cell lines by inducing cell cycle arrest in G0/G1-phase.
ODM-207 suppresses the growth of ER+ patient-derived breast cancer xenograft tumors. ODM-207 was shown to synergize with palbociclib in vitro in ER+ breast cancer cell lines.
ODM-207 targeted several pathways important for cancer progression such as MYC, estrogen response and cell cycle gene signatures.
The combination of ODM-207 and CDK4/6 inhibitor palbociclib achieved greater cell proliferation inhibition than either drug alone at sub IC50 concentrations.
| M.Wt | 375.428 | |
| Formula | C22H21N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-(3,5-dimethylisoxazol-4-yl)-7-methoxy-3-methyl-1-(pyridin-2-ylmethyl)quinolin-2(1H)-one |
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1. Ameratunga M, et al. Br J Cancer. 2020 Dec;123(12):1730-1736.
2. Sun Y, et al. Front Pharmacol. 2021 Jan 26;11:621093.
3. Mäkelä R, et al. Oncotarget. 2021 May 25;12(11):1100-1109.
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