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ODM-209

Chemical Structure : ODM-209

CAS No.: 2231294-95-2

ODM-209 (ODM209)

Catalog No.: PC-49351Not For Human Use, Lab Use Only.

ODM-209 (ODM209) is a potent, selective, orally bioavailable inhibitor of CYP11A1 (cholesterol side-chain cleavage enzyme) with potential antineoplastic activity, inhibits the biosynthesis of pregnenolone.

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    Biological Activity

    ODM-209 (ODM209) is a potent, selective, orally bioavailable inhibitor of CYP11A1 (cholesterol side-chain cleavage enzyme) with potential antineoplastic activity, inhibits the biosynthesis of pregnenolone.
    ODM-209 inhibits the proliferation of hormone-positive tumor cells.
    CYP11A1, a mitochondrial enzyme, catalyzes the conversion of cholesterol to pregnenolone (Preg), which is the first rate-limiting step in steroid hormone biosynthesis.

    Physicochemical Properties

    M.Wt 486.506
    Formula C22H25F3N2O5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    5 -((1-(Methylsulfonyl)piperidin-4-yl)methoxy)-2-((5 -(trifluoromethyl)isoindolin- 2-yl)methyl)-4H-pyran-4-on

    References

    1. Patent EP3558981A1, Pyran dervatives as cyp11a1 (cytochrome p450 monooxygenase 11a1) inhibitors

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