OICR-403184 | PKR inhibitor | Probechem Biochemicals

Chemical Structure : OICR-403184

OICR-403184 (OICR403184)

Catalog No.: PC-27082Not For Human Use, Lab Use Only.

OICR-403184 is a potent, selective inhibitor of RNA-dependent protein kinase PKR with IC50 of 263 nM, shows minimal activity against related eIF2α kinases and BRAF.

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Biological Activity

OICR-403184 is a potent, selective inhibitor of RNA-dependent protein kinase PKR with IC50 of 263 nM, shows minimal activity against related eIF2α kinases and BRAF.

Physicochemical Properties

M.Wt	533.59
Formula	C24H22F3N5O2S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(5-(2-amino-6-methylpyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

References

1. Yin J, et al. J Med Chem. 2026 Jun 22. doi: 10.1021/acs.jmedchem.5c03664.

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OICR-403184 (OICR403184)

Biological Activity

Physicochemical Properties

References

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