OJT008 | Mtb MetAP1 inhibitor | Probechem Biochemicals

Chemical Structure : OJT008

OJT008 (OJT 008)

Catalog No.: PC-21577Not For Human Use, Lab Use Only.

OJT008 is a small molecule Mtb. MetAP inhibitor against M. tuberculosis, has MIC50 of 0.063 µg/mL against both active and MDR Mtb.

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Biological Activity

OJT008 is a small molecule Mtb. MetAP inhibitor against M. tuberculosis, has MIC50 of 0.063 µg/mL against both active and MDR Mtb.
OJT008 inhibits MtMetAP1c activated with CoCl2 and NiCl2 were 11 µM and 40 µM, respectively, strongly binds to both metal-activated MtMetAP1c.
OJT008 also inhibits the enzyme methionine aminopeptidase 1 of L. major (MetAP1Lm).
OJT008 showed potent leishmanicidal activity and remarkable selectivity indexes in vitro (EC50=0.24 uM).
OJT008 exhibits significant antileishmanial activity in vitro and in vivo.

Physicochemical Properties

M.Wt	324.81
Formula	C18H17ClN4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-benzyl-5-chloro-N,6-dimethyl-2-(pyridin-2-yl)pyrimidin-4-amine

References

1. Rodriguez F, et al. Antimicrob Agents Chemother. 2020 May 21;64(6):e01422-19.

2. Onyenaka C, et al. Int J Mol Sci. 2023 Dec 5;24(24):17142.

OJT008 (OJT 008)

Biological Activity

Physicochemical Properties

References

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