Catalog No.: PC-38743Not For Human Use, Lab Use Only.
ONO-8430506 is a highly potent, orally available autotaxin (ATX) inhibitor with IC50 of 10 nM (recombinant human ATX), exhibits LysoPLD inhibitory activity in human plasma with IC50 of 5.5 nM.
ONO-8430506 is a highly potent, orally available autotaxin (ATX) inhibitor with IC50 of 10 nM (recombinant human ATX), exhibits LysoPLD inhibitory activity in human plasma with IC50 of 5.5 nM.
ONO-8430506 suppressed LPA formation in plasma and decreased rat intraurethral pressure in a dose-dependent manner。
ONO-8430506 enhances the antitumor effect of paclitaxel in breast cancer model.
ONO-8430506 (30 mg/kg) ameliorates neuropathic pain derived from lumbar spinal canal stenosis.
