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OP-5244

Chemical Structure : OP-5244

CAS No.: 2381268-71-7

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OP-5244 (OP5244)

Catalog No.: PC-72269Not For Human Use, Lab Use Only.

OP-5244 is a highly potent, orally bioavailable CD73 inhibitor with biochemical IC50 of 0.25 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    OP-5244 is a highly potent, orally bioavailable CD73 inhibitor with biochemical IC50 of 0.25 nM.
    OP-5244 inhibited adenosine production in both human cancer cells and CD8+ T cells.
    OP-5244 lowered the ratio of ADO/AMP significantly and reversed immunosuppression in mouse models.

    Physicochemical Properties

    M.Wt 537.891
    Formula C19H29ClN5O9P
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    ((R)-2-(((2R,3S,4R,5R)-5-(6-chloro-4-(cyclopentylamino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)-1-hydroxy-3-methoxypropan-2-yl)phosphonic acid

    References

    1. Xiaohui Du, et al. J Med Chem. 2020 Sep 24;63(18):10433-10459.

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