OR-S0 | EZH2 inhibitor | Probechem Biochemicals

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Chemical Structure : OR-S0

OR-S0 (EZH2 inhibitor OR-S0)

Catalog No.: PC-72290Not For Human Use, Lab Use Only.

OR-S0 is a potent, selective EZH2 inhibitor with IC50 of 11 nM, weakly inhibitor EZH1 (IC50=91 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

OR-S0 is a potent, selective EZH2 inhibitor with IC50 of 11 nM, weakly inhibitor EZH1 (IC50=91 nM).
OR-S0 inhibits H3K27me3 in HCT116 cells with IC50 of 24 nM, inhibited the growth of KARPAS‐422 cells in a dose‐dependent manner with GI50 of 210 nM.

Physicochemical Properties

M.Wt	616.763
Formula	C34H44N6O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-7-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)-2,4-dimethyl-2-(morpholinomethyl)benzo[d][1,3]dioxole-5-carboxamide

References

1. Daisuke Honma, et al. Cancer Sci. 2017 Oct;108(10):2069-2078.

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OR-S0 (EZH2 inhibitor OR-S0)

Biological Activity

Physicochemical Properties

References

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