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OR-S0

Chemical Structure : OR-S0

CAS No.: 1809336-90-0

OR-S0

Catalog No.: PC-72290Not For Human Use, Lab Use Only.

OR-S0 is a potent, selective EZH2 inhibitor with IC50 of 11 nM, weakly inhibitor EZH1 (IC50=91 nM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

OR-S0 is a potent, selective EZH2 inhibitor with IC50 of 11 nM, weakly inhibitor EZH1 (IC50=91 nM).
OR-S0 inhibits H3K27me3 in HCT116 cells with IC50 of 24 nM, inhibited the growth of KARPAS‐422 cells in a dose‐dependent manner with GI50 of 210 nM.

Physicochemical Properties

M.Wt 616.763
Formula C34H44N6O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Month
Shipping
Solubility

Chemical Name/SMILES

References

1. Daisuke Honma, et al. Cancer Sci. 2017 Oct;108(10):2069-2078.

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