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OR51E2 antagonist C80

Chemical Structure : OR51E2 antagonist C80

CAS No.: 1241327-01-4

OR51E2 antagonist C80 (Compound 80)

Catalog No.: PC-22324Not For Human Use, Lab Use Only.

OR51E2 antagonist C80 (Compound 80) is an allosteric antagonist and inverse agonist of olfactory receptor OR51E2 with IC50 of 5.2 uM, acts as a negative allosteric modulator (NAM) by significantly decreasing the agonist efficacy.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

OR51E2 antagonist C80 (Compound 80) is an allosteric antagonist and inverse agonist of olfactory receptor OR51E2 with IC50 of 5.2 uM, acts as a negative allosteric modulator (NAM) by significantly decreasing the agonist efficacy.

Physicochemical Properties

M.Wt 447.77
Formula C15H9ClF3N5O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-chloro-3-nitro-N-(4-(5-(trifluoromethyl)-1H-1,2,3-triazol-1-yl)phenyl)benzenesulfonamide

References

1. Tatjana Abaffy, et al. Mol Pharmacol. 2024 May 6:MOLPHARM-AR-2023-000843.

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