ORF9b homodimerization inhibitor EN300

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Chemical Structure : ORF9b homodimerization inhibitor EN300

Catalog No.: PC-24053Not For Human Use, Lab Use Only.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ORF9b homodimerization inhibitor EN300 is a small molecule inhibitor of ORF9b homodimerization, inhibits ORF9b-ORF9b homotypic interaction, inhibits activation of caspase-1 in A549.ORF9b and THP-1.ORF9b cells with IC50 of 0.85 and 17 nM respectively.
EN300 abrogates cytokine release in THP-1 cells, restores IFN-I responses compromised by ORF9b.
EN300 potentiates IFN-I responses upon SARS-CoV-2 infection of A549 lung carcinoma cells.

Physicochemical Properties

M.Wt	244.27
Formula	C14H13FN2O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-amino-2-fluorophenyl)-2-phenylacetamide

References

1. Zodda E, et al. J Med Virol. 2025 Feb;97(2):e70145.

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