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ORF9b homodimerization inhibitor Y600

Chemical Structure : ORF9b homodimerization inhibitor Y600

CAS No.: 896654-08-3

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ORF9b homodimerization inhibitor Y600

Catalog No.: PC-24054Not For Human Use, Lab Use Only.

ORF9b homodimerization inhibitor Y600 is a small molecule inhibitor of ORF9b homodimerization, inhibits ORF9b-ORF9b homotypic interaction, inhibits activation of caspase-1 in A549.ORF9b and THP-1.ORF9b cells with IC50 of 1 and 4 nM respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ORF9b homodimerization inhibitor Y600 is a small molecule inhibitor of ORF9b homodimerization, inhibits ORF9b-ORF9b homotypic interaction, inhibits activation of caspase-1 in A549.ORF9b and THP-1.ORF9b cells with IC50 of 1 and 4 nM respectively.
Y600 abrogates cytokine release in THP-1 cells, restores IFN-I responses compromised by ORF9b.
Y600 potentiates IFN-I responses upon SARS-CoV-2 infection of A549 lung carcinoma cells.

Physicochemical Properties

M.Wt 255.36
Formula C17H21NO
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-((2,3-dihydro-1H-inden-2-yl)amino)-5,5-dimethylcyclohex-2-en-1-one

References

1. Zodda E, et al. J Med Virol. 2025 Feb;97(2):e70145.

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