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Chemical Structure : ORY-1001
CAS No.: 1431326-61-2
Catalog No.: PC-43206Not For Human Use, Lab Use Only.
ORY-1001 (RG-6016) is a highly potent, selective inhibitor of lysine-specific demethylase KDM1A (LSD1) with IC50 of 18 nM, displays high selectivity for KDM1A over other FAD-containing monoamine oxidases.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $548 | In stock | |
| 100 mg | Get quote |
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ORY-1001 (RG-6016, Iadademstat) is a highly potent, selective inhibitor of lysine-specific demethylase KDM1A (LSD1) with IC50 of 18 nM, displays high selectivity for KDM1A over other FAD-containing monoamine oxidases.
ORY-1001 (RG-6016, Iadademstat) exhibits low nanomolar cellular activity (EC50 < 1 nM) in the THP1 differentiation assay and induces the CD11b marker within 6 hr of treatment in FACS based differentiation assay in THP1 cell line.
ORY-1001 (RG-6016, Iadademstat) induces H3K4me2 accumulation on KDM1A target genes, blast differentiation, and reduction of leukemic stem cell capacity in AML.
ORY-1001 (RG-6016, Iadademstat) exhibits potent synergy with standard-of-care drugs and selective epigenetic inhibitors, reduces growth of AML xenograft models.
| M.Wt | 303.2704 | |
| Formula | C15H24Cl2N2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: < 6.8 mg/mL |
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| Chemical Name/SMILES |
trans-N1-(2-Phenylcyclopropyl)cyclohexane-1,4-diamine dihydrochloride |
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1. Maes T, et al. Cancer Cell. 2018 Mar 12;33(3):495-511.e12.
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