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Chemical Structure : OSBPL7 inhibitor Cpd A
Catalog No.: PC-72588Not For Human Use, Lab Use Only.
ABCA1 inducer Cpd A (Cpd A) is a small molecule inducer of ABCA1-mediated cholesterol efflux that targets Oxysterol Binding Protein Like 7 (OSBPL7).
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ABCA1 inducer Cpd A (Cpd A) is a small molecule inducer of ABCA1-mediated cholesterol efflux that targets Oxysterol Binding Protein Like 7 (OSBPL7).
Cpd A displays little to no binding affinity to the CB1R (Ki>10 uM).
Cpd A increases plasma membrane ABCA1 in cultured human podocytes, and significantly increases ABCA1-dependent cholesterol efflux at 10 uM.
Cpd A significantly increased apoAI-mediated cholesterol efflux at 10 uM.
Cpd A protects from kidney injury in a mouse model of adriamycin-induced nephropathy.
| M.Wt | 463.278 | |
| Formula | C20H19Cl2F3N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Matthew B Wright, et al. Nat Commun. 2021 Aug 2;12(1):4662.
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