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OSBPL7 inhibitor Cpd A

Chemical Structure : OSBPL7 inhibitor Cpd A

CAS No.: 1637533-03-9

OSBPL7 inhibitor Cpd A (ABCA1 inducer Cpd A)

Catalog No.: PC-72588Not For Human Use, Lab Use Only.

ABCA1 inducer Cpd A (Cpd A) is a small molecule inducer of ABCA1-mediated cholesterol efflux that targets Oxysterol Binding Protein Like 7 (OSBPL7).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ABCA1 inducer Cpd A (Cpd A) is a small molecule inducer of ABCA1-mediated cholesterol efflux that targets Oxysterol Binding Protein Like 7 (OSBPL7).
    Cpd A displays little to no binding affinity to the CB1R (Ki>10 uM).
    Cpd A increases plasma membrane ABCA1 in cultured human podocytes, and significantly increases ABCA1-dependent cholesterol efflux at 10 uM.
    Cpd A significantly increased apoAI-mediated cholesterol efflux at 10 uM.
    Cpd A protects from kidney injury in a mouse model of adriamycin-induced nephropathy.

    Physicochemical Properties

    M.Wt 463.278
    Formula C20H19Cl2F3N2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    6-(3,4-dichlorophenyl)-N-((1R,2R)-2-hydroxycyclohexyl)-5-(2,2,2-trifluoroethoxy)picolinamide

    References

    1. Matthew B Wright, et al. Nat Commun. 2021 Aug 2;12(1):4662.

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