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OSMI-1

Chemical Structure : OSMI-1

CAS No.: 1681056-61-0

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OSMI-1 (OSMI1)

Catalog No.: PC-62387Not For Human Use, Lab Use Only.

OSMI-1 is a cell-permeable, small molecule O-GlcNAc transferase (OGT) inhibitor with IC50 of 2.7 uM.

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10 mg $128 In stock
25 mg $228 In stock
50 mg $388 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

OSMI-1 is a cell-permeable, small molecule O-GlcNAc transferase (OGT) inhibitor with IC50 of 2.7 uM.
OSMI-1 inhibits protein O-GlcNAcylation in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans.
OSMI-1 also significantly decreases HSV replication.

Physicochemical Properties

M.Wt 563.64
Formula C28H25N3O6S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

αR-[[(1,2-dihydro-2-oxo-6-quinolinyl)sulfonyl]amino]-N-(2-furanylmethyl)-2-methoxy-N-(2-thienylmethyl)-benzeneacetamide

References

1. Ortiz-Meoz RF, et al. ACS Chem Biol. 2015 Jun 19;10(6):1392-7.

2. Angelova M, et al. J Virol. 2015 Aug;89(16):8474-83.

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