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Chemical Structure : OSMI-4
CAS No.: 2260791-14-6
Catalog No.: PC-35723Not For Human Use, Lab Use Only.
OSMI-4 (OGT inhibitor 4b) is a novel potent, selective, cell-active O-linked N-acetylglucosamine transferase (OGT) inhibitor with EC50 of ~3 uM.
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|---|---|---|---|
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| 5 mg | $428 | In stock | |
| 10 mg | $728 | In stock | |
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OSMI-4 (OGT inhibitor 4b) is a novel potent, selective, cell-active O-linked N-acetylglucosamine transferase (OGT) inhibitor with EC50 of ~3 uM.
OSMI-4 reduces O-GlcNAc levels almost completely by 5 μM (O-GlcNAc (RL-2) blot of HEK293T cell lysates after treatment).
OSMI-4 is the best OGT inhibitor reported to date, and it is especially attractive for probing OGT’s complex biology.
| M.Wt | 604.089 | |
| Formula | C27H26ClN3O7S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
ethyl (R)-N-(2-((7-chloro-2-oxo-1,2-dihydroquinoline)-6-sulfonamido)-2-(2-methoxyphenyl)acetyl)-N-(thiophen-2-ylmethyl)glycinate |
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1. Martin SES, et al. J Am Chem Soc. 2018 Oct 24;140(42):13542-13545.
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