OSU-6162 hydrochloride |CAS:156907-84-5 Probechem Biochemicals

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Chemical Structure : OSU-6162 hydrochloride

OSU-6162 hydrochloride (PNU-96391;(-)-OSU6162;OSU6162)

Catalog No.: PC-70063Not For Human Use, Lab Use Only.

A potent dopamine stabilizer with Ki of 447 and 1305 nM for D2 and D3 receptors respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent dopamine stabilizer with Ki of 447 and 1305 nM for D2 and D3 receptors respectively; lacks high affinity for various neuroreceptors in vitro (Ki>1 uM); has antipsychotic, anti-addictive and anti-Parkinsonian effects in animal studies; the (R) enantiomer (+)-OSU-6162 has higher efficacy at 5-HT2A but lower D2 affinity.

Physicochemical Properties

M.Wt	589.17
Formula	C33H41ClN6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-(3-(methylsulfonyl)phenyl)-1-propylpiperidine hydrochloride

References

1. Ekesbo A, et al. Neuroreport. 1997 Jul 28;8(11):2567-70.

2. Nichols NF, et al. Neuropharmacology. 2002 Oct;43(5):817-24.

3. Kara E, et al. Br J Pharmacol. 2010 Nov;161(6):1343-50.

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OSU-6162 hydrochloride (PNU-96391;(-)-OSU6162;OSU6162)

Biological Activity

Physicochemical Properties

References

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