OT-7999 | A3 adenosine antagonist | Probechem Biochemicals

Chemical Structure : OT-7999

OT-7999 (OT7999, OT 7999)

Catalog No.: PC-20643Not For Human Use, Lab Use Only.

OT-7999 (OT7999) is a potent and selective adenosine A3 receptor antagonist with Ki of 0.61 nM (human A3 receptor) in radioligand binding assays.

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Biological Activity

OT-7999 (OT7999) is a potent and selective adenosine A3 receptor antagonist with Ki of 0.61 nM (human A3 receptor) in radioligand binding assays.
OT-7999 displays >16,000-fold selective for human A3 versus rat A3 receptors.
OT-7999 is high selective for human A3 versus hA1, hA2A, and A2B receptors (>16,000-fold).
OT-7999 significantly decreased intraocular pressure in a monkey model of intraocular pressure by eye-drop administration.

Physicochemical Properties

M.Wt	360.34
Formula	C17H15F3N6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	FC(C1=CC=C(C2=NN3C(CCCC)=NC4=C(N=CN4)C3=N2)C=C1)(F)F

References

1. Okamura T, et al. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3775-9.

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OT-7999 (OT7999, OT 7999)

Biological Activity

Physicochemical Properties

References

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