Catalog No.: PC-45487Not For Human Use, Lab Use Only.
OTS514 (OTS-514) is a highly potent and selective inhibitor of T-lymphokine-activated killer-cell-originated protein kinase (TOPK, PDZ-binding kinase/PBK) with IC50 of 2.6 nM.
OTS514 (OTS-514) is a highly potent and selective inhibitor of T-lymphokine-activated killer-cell-originated protein kinase (TOPK, PDZ-binding kinase/PBK) with IC50 of 2.6 nM.
OTS514 shows selectivity against a panel of 60 kinases (at 0.2 uM, 11.5-18.5% inhibition).
OTS514 strongly suppresses the growth of TOPK-positive cancer cells.
OTS514 demonstrates in vivo efficacy but causes severe hematopoietic toxicity.
