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Chemical Structure : OV350
Catalog No.: PC-21203Not For Human Use, Lab Use Only.
OV350 (OV-350) is a potent, selective and direct K+-Cl- cotransporter KCC2 agonist with EC50 of 261.4 nM, with no effect on KCC2 plasma membrane accumulation and phosphorylation.
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OV350 (OV-350) is a potent, selective and direct K+-Cl- cotransporter KCC2 agonist with EC50 of 261.4 nM, with no effect on KCC2 plasma membrane accumulation and phosphorylation.
OV350 reduces neuronal Cl− accumulation and slows the development of seizure-like events in brain slices, limits neuronal hyperexcitability.
OV350 prevents the development of BDZ-RSE, restores the efficacy of Diazepam (DZ) to terminate ongoing BDZ-RSE, reduces neuronal cell death 48 h after BDZ-RSE.
| M.Wt | 605.74 | |
| Formula | C35H39N7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rebecca Jarvis, et al. Cell Rep Med. 2023 Mar 21;4(3):100957.
2. Patent WO2021180952A1.
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