Catalog No.: PC-21203Not For Human Use, Lab Use Only.
OV350 (OV-350) is a potent, selective and direct K+-Cl- cotransporter KCC2 agonist with EC50 of 261.4 nM, with no effect on KCC2 plasma membrane accumulation and phosphorylation.
OV350 (OV-350) is a potent, selective and direct K+-Cl- cotransporter KCC2 agonist with EC50 of 261.4 nM, with no effect on KCC2 plasma membrane accumulation and phosphorylation.
OV350 reduces neuronal Cl− accumulation and slows the development of seizure-like events in brain slices, limits neuronal hyperexcitability.
OV350 prevents the development of BDZ-RSE, restores the efficacy of Diazepam (DZ) to terminate ongoing BDZ-RSE, reduces neuronal cell death 48 h after BDZ-RSE.
