Chemical Structure : OXGR1 agonist A-1
CAS No.:
84703-35-5
OXGR1 agonist A-1
Catalog No.: PC-26371Not For Human Use, Lab Use Only.
OXGR1 agonist A-1 is a potent and selective OXGR1 (Oxoglutarate Receptor 1, GPR99) agonist, activates Gq signaling of OXGR1 with EC50 of 626.5 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
OXGR1 agonist A-1 is a potent and selective OXGR1 (Oxoglutarate Receptor 1, GPR99) agonist, activates Gq signaling of OXGR1 with EC50 of 626.5 nM.
A-1 activates OXGR1 with a potency approximately 60 times stronger compared with α-KG.
A-1 shows no detectable activity for GPR91.
OXGR1-F113L mutant reduced the potency of A-1 by more than 10,000-fold.
A-1 promoted phosphorylation of MYL9 and MLCK expression in VSMCs comparable to α-KG.
A-1 (80 uM) obviously improved rosacea-related phenotypes when applied topically to the back skins of mice.
A-1 mitigates erythema and inflammation with efficacy comparable to first-line therapy while offering enhanced safety in rosacea-like models.
Physicochemical Properties
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M.Wt
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191.20
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Formula
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C6H9NO4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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methyl (1,1-dioxido-2,3-dihydrothiophen-3-yl)carbamate
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References
1. Xiao W, et al. Cell. 2026 Mar 5:S0092-8674(26)00164-9. doi: 10.1016/j.cell.2026.01.036.
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