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Chemical Structure : Oclacitinib maleate
CAS No.: 1640292-55-2
Catalog No.: PC-22618Not For Human Use, Lab Use Only.
Oclacitinib (PF-03394197) maleate is a potent JAK inhibitor with IC50 of 10, 18, 99, and 84 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
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|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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Oclacitinib (PF-03394197) maleate is a potent JAK inhibitor with IC50 of 10, 18, 99, and 84 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
Oclacitinib (PF-03394197) does not significantly inhibit a panel of 38 other kinases when tested at 1 uM.
Oclacitinib (PF-03394197) inhibits IL-2, IL-4, IL-6, IL-13, and IL-31 with IC50's ranging from 36 to 249 nM, much less potent against erythropoietin and GM-CSF.
Oclacitinib (PF-03394197) inhibited JAK1-dependent cytokine receptor complexes involved in inflammation and pruritus, common clinical signs in canine allergic skin disease.
| M.Wt | 453.51 | |
| Formula | C19H27N5O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-methyl-1-((1r,4r)-4-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)methanesulfonamide maleate |
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1. Fukuyama T, et al. Eur J Pharmacol. 2017 Jan 5;794:20-26.
2. Panteri A, et al. Vet Dermatol. 2016 Feb;27(1):22-e7.
3. Gonzales AJ, et al. J Vet Pharmacol Ther. 2014 Aug;37(4):317-24.
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