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Olomoucine

Chemical Structure : Olomoucine

CAS No.: 101622-51-9

Olomoucine (CDK inhibitor)

Catalog No.: PC-60188Not For Human Use, Lab Use Only.

Olomoucine is a potent, ATP-competetive CDKs inhibitor with IC50 of 7, 7, 7, 3 uM for Cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk/p35 kinase.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Olomoucine is a potent, ATP-competetive CDKs inhibitor with IC50 of 7, 7, 7, 3 uM for Cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk/p35 kinase.
Olomoucine also inhibits ERK1/MAP kinase (IC50=25 uM).
Olomoucine inhibits the starfish oocyte G2/M transition in vivo.

Physicochemical Properties

M.Wt 298.35
Formula C15H18N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(2-Hydroxyethylamino)-6- benzylamino-9-methylpurine

References

1. Veselý J, et al. Eur J Biochem. 1994 Sep 1;224(2):771-86.

2. Tsou YC, et al. Neurosci Lett. 2016 Aug 15;628:186-93.

3. Fei XF, et al. Brain Res. 2009 Apr 6;1264:85-97.

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