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Omarigliptin

Chemical Structure : Omarigliptin

CAS No.: 1226781-44-7

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Omarigliptin (MK-3102, MK3102)

Catalog No.: PC-44866Not For Human Use, Lab Use Only.

Omarigliptin (MK-3102) is a potent and selective DPP-4 inhibitor with IC50 of 1.4 nM.

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10 mg $128 In stock
25 mg $198 In stock
50 mg $298 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Omarigliptin (MK-3102) is a potent and selective DPP-4 inhibitor with IC50 of 1.4 nM.
Omarigliptin (MK-3102) shows high selectivity against QPP, DPP8,FAP (IC50>20 uM).
Omarigliptin (MK-3102) is efficacious in the diabetes PD model and excellent pharmacokinetic profile.

Physicochemical Properties

M.Wt 398.4275
Formula C17H20F2N4O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2H-Pyran-3-amine, 2-(2,5-difluorophenyl)-5-[2,6-dihydro-2-(methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-, (2R,3S,5R)-

References

1. Biftu T, et al. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5361-6.

2. Biftu T, et al. J Med Chem. 2014 Apr 24;57(8):3205-12.

3. Burness CB. Drugs. 2015 Nov;75(16):1947-52.

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