Chemical Structure : Ombrabulin hydrochloride
CAS No.:
253426-24-3
Ombrabulin hydrochloride
(AVE-8062;AVE-8062A;AC-7700)
Catalog No. : PC-45442Not For Human Use, Lab Use Only.
A novel combretastatin A-4 derivative that strongly stanches tumour blood flow and inhibits growth of tumours developing in various tissues and organ.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4544201
Biological Activity
A novel combretastatin A-4 derivative that strongly stanches tumour blood flow and inhibits growth of tumours developing in various tissues and organ; a vascular-disrupting agent.
Ovarian Cancer
Phase 2 Clinical
Physicochemical Properties
M.Wt
438.9019
Formula
C21H27ClN2O6
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO; Methanol: ≥ 30 mg/mL
Chemical Name/SMILES
Propanamide, 2-amino-3-hydroxy-N-[2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl]-, hydrochloride (1:1), (2S)-
References
1. Hori K, et al. Br J Cancer. 2002 May 20;86(10):1604-14.
2. Kim TJ, et al. Cancer Res. 2007 Oct 1;67(19):9337-45.
3. Sessa C, et al. Clin Cancer Res. 2013 Sep 1;19(17):4832-42.
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