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Chemical Structure : Omilancor
CAS No.: 1912399-75-7
Catalog No.: PC-72523Not For Human Use, Lab Use Only.
Omilancor (BT-11) is a locally-acting, first-in-class, small molecule that selectively activates the Lanthionine Synthetase C-like 2 (LANCL2) pathway.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $228 | In stock | |
| 25 mg | $388 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Omilancor (BT-11) is a locally-acting, first-in-class, small molecule that selectively activates the Lanthionine Synthetase C-like 2 (LANCL2) pathway.
Through LANCL2 activation, Omilancor also modulates Treg stability and function through a two-layer mechanism: (1) regulation of FOXP3 activity through immunometabolic pathways, and (2) synergism with the IL-2/STAT5 signaling axis of Treg cells; omilancor regulates late-stage glycolysis and promotes oxidative metabolism in regulatory T cells (Treg).
Omilancor ameliorates disease severity, epidermal hyperplasia and acanthosis in an imiquimod-induced mouse model of psoriasis.
| M.Wt | 528.576 | |
| Formula | C30H24N8O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
piperazine-1,4-diylbis((6-(1H-benzo[d]imidazol-2-yl)pyridin-2-yl)methanone) |
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1. Adria Carbo, et al. J Med Chem. 2016 Nov 23;59(22):10113-10126.
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