Ophiobolin A | Calmodulin inhibitor | Probechem Biochemicals

Chemical Structure : Ophiobolin A

CAS No.: 4611-05-6

Ophiobolin A (OphA)

Catalog No.: PC-72370Not For Human Use, Lab Use Only.

Ophiobolin A (OphA) is a potent, covalent CaM inhibitor, with broad toxicity against plants, microbes, and cancer cells, OphA also is a K-Ras4B but not an H-Ras selective inhibitor.

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5 mg	$598	In stock
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Biological Activity

Ophiobolin A (OphA) is a potent, covalent calmodulin (CaM) inhibitor, with broad toxicity against plants, microbes, and cancer cells, OphA also is a K-Ras4B but not an H-Ras selective inhibitor.
OphA disrupts membrane organization of K-Ras in a CaM-dependent manner and blocked the growth of cancer stem cell enriched spheroids derived from breast cancer cell lines.

Physicochemical Properties

M.Wt	400.559
Formula	C25H36O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Spiro[dicyclopenta[a,d]cyclooctene-3(2H),2′(3′H)-furan]-6-carboxaldehyde, 1,3a,4,4′,5′,6a,7,8,9,9a,10,10a-dodecahydro-9-hydroxy-3′,9,10a-trimethyl-5′-(2-methyl-1-propen-1-yl)-7-oxo-, (2′S,3′S,3aR,5′R,6aS,9R,9aS,10aR)-

References

1. Au TK, Chick WS, Leung PC. Life Sci. 2000 Jul 7; 67(7):733-42.

2. Leung PC, Taylor WA, Wang JH, Tipton CL. J Biol Chem. 1984 Mar 10; 259(5):2742-7.

3. Najumudeen AK, et al. Oncogene. 2016 Oct 6; 35(40):5248-5262.

Ophiobolin A (OphA)

Biological Activity

Physicochemical Properties

References

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