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Chemical Structure : Ophiobolin A
CAS No.: 4611-05-6
Catalog No.: PC-72370Not For Human Use, Lab Use Only.
Ophiobolin A (OphA) is a potent, covalent CaM inhibitor, with broad toxicity against plants, microbes, and cancer cells, OphA also is a K-Ras4B but not an H-Ras selective inhibitor.
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Ophiobolin A (OphA) is a potent, covalent calmodulin (CaM) inhibitor, with broad toxicity against plants, microbes, and cancer cells, OphA also is a K-Ras4B but not an H-Ras selective inhibitor.
OphA disrupts membrane organization of K-Ras in a CaM-dependent manner and blocked the growth of cancer stem cell enriched spheroids derived from breast cancer cell lines.
| M.Wt | 400.559 | |
| Formula | C25H36O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Spiro[dicyclopenta[a,d]cyclooctene-3(2H),2′(3′H)-furan]-6-carboxaldehyde, 1,3a,4,4′,5′,6a,7,8,9,9a,10,10a-dodecahydro-9-hydroxy-3′,9,10a-trimethyl-5′-(2-methyl-1-propen-1-yl)-7-oxo-, (2′S,3′S,3aR,5′R,6aS,9R,9aS,10aR)- |
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1. Au TK, Chick WS, Leung PC. Life Sci. 2000 Jul 7; 67(7):733-42.
2. Leung PC, Taylor WA, Wang JH, Tipton CL. J Biol Chem. 1984 Mar 10; 259(5):2742-7.
3. Najumudeen AK, et al. Oncogene. 2016 Oct 6; 35(40):5248-5262.
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