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Optovin

Chemical Structure : Optovin

CAS No.: 348575-88-2

Optovin (Photoactivated TRPA1 ligand)

Catalog No.: PC-43222Not For Human Use, Lab Use Only.

Optovin is a reversible photoactivated TRPA1 ligand that can be photoactivated by violet light, enables light-mediated neuronal excitation in treated animals with EC50 of 2 uM at 387 nm (violet), but not to 485 nm (blue), 560 nm (green) or longer wavelengths.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Optovin is a reversible photoactivated TRPA1 ligand that can be photoactivated by violet light, enables light-mediated neuronal excitation in treated animals with EC50 of 2 uM at 387 nm (violet), but not to 485 nm (blue), 560 nm (green) or longer wavelengths.
Optovin shows activity on zebrafish, mouse neurons, and recombinant human protein, enables repeated photoactivation of motor behaviors in wild-type zebrafish and mice.

Physicochemical Properties

M.Wt 315.4132
Formula C15H13N3OS2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 37 mg/mL

Chemical Name/SMILES

4-Thiazolidinone, 5-[[2,5-dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-2-thioxo-

References

1. Kokel D, et al. Nat Chem Biol. 2013 Apr;9(4):257-63.

2. Lu Y, et al. Anesthesiology. 2016 Dec;125(6):1171-1180.

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