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Org 27569

Chemical Structure : Org 27569

CAS No.: 868273-06-7

Org 27569 (Org-27569;Org27569)

Catalog No.: PC-43465Not For Human Use, Lab Use Only.

Org 27569 is a potent, selective, allosteric modulator of cannabinoid CB1 receptor, significantly increases the binding of the CB1 receptor agonist [3H]CP 55,940 with pKb of 5.67.

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25 mg $138 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Org 27569 is a potent, selective, allosteric modulator of cannabinoid CB1 receptor, significantly increases the binding of the CB1 receptor agonist [3H]CP 55,940 with pKb of 5.67.
Org 27569 reduces food consumption in rats, produces CB1-independent hypophagic effects and does not affect the discriminative stimulus effects of anandamide (AEA).

Physicochemical Properties

M.Wt 409.95
Formula C24H28ClN3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 52.2 mg/mL

Chemical Name/SMILES

1H-Indole-2-carboxamide, 5-chloro-3-ethyl-N-[2-[4-(1-piperidinyl)phenyl]ethyl]-

References

1. Price MR, et al. Mol Pharmacol. 2005 Nov;68(5):1484-95.

2. Erdozain AM, et al. Biochem Pharmacol. 2012 Jan 15;83(2):260-8.

3. Fay JF, et al. J Biol Chem. 2012 Sep 28;287(40):33873-82.

4. Gamage TF, et al. Behav Pharmacol. 2014 Apr;25(2):182-5.

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