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Orpinolide

Chemical Structure : Orpinolide

CAS No.:

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Orpinolide

Catalog No.: PC-22607Not For Human Use, Lab Use Only.

Orpinolide is a synthetic withanolide analog with potent antileukemic properties, directly targets oxysterol-binding protein OSBP, disrupts Golgi homeostasis via a mechanism that requires active phosphatidylinositol 4-phosphate (PtdIns4P, PI4P) signaling at ER-Golgi membrane interface.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Orpinolide is a synthetic withanolide analog with potent antileukemic properties, directly targets oxysterol-binding protein OSBP, disrupts Golgi homeostasis via a mechanism that requires active phosphatidylinositol 4-phosphate (PtdIns4P, PI4P) signaling at ER-Golgi membrane interface.

    Physicochemical Properties

    M.Wt 483.69
    Formula C30H45NO4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-6-((S)-1-((3S,8S,9S,10R,13S,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethyl)-4-morpholino-5,6-dihydro-2H-pyran-2-one

    References

    1. Marko Cigler, et al. Nat Chem Biol. 2024 Jun 21. doi: 10.1038/s41589-024-01614-4.

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