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Osilodrostat

Chemical Structure : Osilodrostat

CAS No.: 928134-65-0

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Osilodrostat (LCI699, LCI-699)

Catalog No.: PC-38385Not For Human Use, Lab Use Only.

Osilodrostat (LCI 699) is a potent, orally active inhibitor of human 11β-hydroxylase and aldosterone synthase with IC50 of 2.5 and 0.7 nM, respectively.

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25 mg $188 In stock
50 mg $328 In stock
100 mg $548 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Osilodrostat (LCI 699) is a potent, orally active inhibitor of human 11β-hydroxylase and aldosterone synthase with IC50 of 2.5 and 0.7 nM, respectively.
Osilodrostat (LCI 699) reduces serum aldosterone, and has benefit in the treatment of hypertension.

Physicochemical Properties

M.Wt 227.237
Formula C13H10FN3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-4-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-3-fluorobenzonitrile

References

1. Amar L, et al. Hypertension. 2010 Nov;56(5):831-8.

2. Calhoun DA, et al. Circulation. 2011 Nov 1;124(18):1945-55.

3. Bertagna X, et al. J Clin Endocrinol Metab. 2014 Apr;99(4):1375-83.

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