Chemical Structure : Otenabant hydrochloride
CAS No.:
686347-12-6
Otenabant hydrochloride
(CP 945598 Hydrochloride;CP-945598 Hydrochloride;CP945598 Hydrochloride)
Catalog No. : PC-42724Not For Human Use, Lab Use Only.
A potent, and selective CB1 receptor antagonist with Ki of 0.7 nM/0.12 nM in binding and functional assays respectively.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4272401
Biological Activity
A potent, and selective CB1 receptor antagonist with Ki of 0.7 nM/0.12 nM in binding and functional assays respectively; has low affinity (Ki=7600 nM) for human CB2 receptors; reverses cannabinoid agonist mediated responses, reduces food intake, and increases energy expenditure and fat oxidation in rodents.
Obesity
Phase 3 Discontinued
Physicochemical Properties
M.Wt
546.8792
Formula
C25H26Cl3N7O
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: 1 mg/mL
Chemical Name/SMILES
4-Piperidinecarboxamide, 1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-(ethylamino)-, hydrochloride (1:1)
References
1. Fulp A, et al. J Med Chem. 2012 Nov 26;55(22):10022-32.
2. Hadcock JR, et al. Biochem Biophys Res Commun. 2010 Apr 2;394(2):366-71.
3. Aronne LJ, et al. Obesity (Silver Spring). 2011 Jul;19(7):1404-14.
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