Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Others-Other Targets-Oxybipin-2
Oxybipin-2

Chemical Structure : Oxybipin-2

CAS No.:

Add to Favorites

Oxybipin-2 (Oxybipin 2, Oxybipin2)

Catalog No.: PC-22604Not For Human Use, Lab Use Only.

Oxybipin-2 is a potent and selective inhibitor of oxysterol-binding protein (OSBP), inhibits OSBP–22-NBD-Chol interaction with IC50 of 13 nM, impair retrograde trafficking.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Oxybipin-2 is a potent and selective inhibitor of oxysterol-binding protein (OSBP), inhibits OSBP–22-NBD-Chol interaction with IC50 of 13 nM, impair retrograde trafficking.
    Oxybipin-2 do not target other sterol transporters and only stabilized OSBP in intact cells.
    Oxybipin-2 could completely inhibit the transport of cholesterol in liposomes.
    Oxybipin-2 causes OSBP localization to the Golgi, trans-Golgi fragmentation and inhibition of STxB trafficking.
    Oxybipin-2 is toxic to the leukemia cell lines Jurkat (EC50=162 nM), MOLM13 (EC50 = 120 nM) and KBM7 (EC50 = 200 nM).
    Oxybipin-2 inhibits retrograde trafficking and Shiga toxin cytotoxicity.

    Physicochemical Properties

    M.Wt 660.98
    Formula C39H68N2O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    tert-butyl (3-(4-(3-((4R)-4-((3S,10R,13R,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)propoxy)butoxy)propyl)carbamate

    References

    1. Nianzhe He, et al. Nat Chem Biol. 2024 Jun 21. doi: 10.1038/s41589-024-01653-x.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: