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Oxybipin-2

Chemical Structure : Oxybipin-2

CAS No.:

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Oxybipin-2 (Oxybipin 2)

Catalog No.: PC-22604Not For Human Use, Lab Use Only.

Oxybipin-2 is a potent and selective inhibitor of oxysterol-binding protein (OSBP), inhibits OSBP–22-NBD-Chol interaction with IC50 of 13 nM, impair retrograde trafficking.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Oxybipin-2 is a potent and selective inhibitor of oxysterol-binding protein (OSBP), inhibits OSBP–22-NBD-Chol interaction with IC50 of 13 nM, impair retrograde trafficking.
Oxybipin-2 do not target other sterol transporters and only stabilized OSBP in intact cells.
Oxybipin-2 could completely inhibit the transport of cholesterol in liposomes.
Oxybipin-2 causes OSBP localization to the Golgi, trans-Golgi fragmentation and inhibition of STxB trafficking.
Oxybipin-2 is toxic to the leukemia cell lines Jurkat (EC50=162 nM), MOLM13 (EC50 = 120 nM) and KBM7 (EC50 = 200 nM).
Oxybipin-2 inhibits retrograde trafficking and Shiga toxin cytotoxicity.

Physicochemical Properties

M.Wt 660.98
Formula C39H68N2O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

tert-butyl (3-(4-(3-((4R)-4-((3S,10R,13R,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)propoxy)butoxy)propyl)carbamate

References

1. Nianzhe He, et al. Nat Chem Biol. 2024 Jun 21. doi: 10.1038/s41589-024-01653-x.

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