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Chemical Structure : Oxybipin-2
Catalog No.: PC-22604Not For Human Use, Lab Use Only.
Oxybipin-2 is a potent and selective inhibitor of oxysterol-binding protein (OSBP), inhibits OSBP–22-NBD-Chol interaction with IC50 of 13 nM, impair retrograde trafficking.
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Oxybipin-2 is a potent and selective inhibitor of oxysterol-binding protein (OSBP), inhibits OSBP–22-NBD-Chol interaction with IC50 of 13 nM, impair retrograde trafficking.
Oxybipin-2 do not target other sterol transporters and only stabilized OSBP in intact cells.
Oxybipin-2 could completely inhibit the transport of cholesterol in liposomes.
Oxybipin-2 causes OSBP localization to the Golgi, trans-Golgi fragmentation and inhibition of STxB trafficking.
Oxybipin-2 is toxic to the leukemia cell lines Jurkat (EC50=162 nM), MOLM13 (EC50 = 120 nM) and KBM7 (EC50 = 200 nM).
Oxybipin-2 inhibits retrograde trafficking and Shiga toxin cytotoxicity.
| M.Wt | 660.98 | |
| Formula | C39H68N2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nianzhe He, et al. Nat Chem Biol. 2024 Jun 21. doi: 10.1038/s41589-024-01653-x.
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