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Oxythiamine chloride hydrochloride

Chemical Structure : Oxythiamine chloride hydrochloride

CAS No.: 614-05-1

Oxythiamine chloride hydrochloride

Catalog No.: PC-63371Not For Human Use, Lab Use Only.

Oxythiamine chloride is a small molecule transketolase inhibitor with Kd of 33 nM, shows functional assay of human transketolase inhibition in HCT-116 cells with EC50 of 26 nM.

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Biological Activity

Oxythiamine chloride hydrochloride is a small molecule transketolase inhibitor with Kd of 33 nM, shows functional assay of human transketolase inhibition in HCT-116 cells with EC50 of 26 nM.
Oxythiamine induces G1 arrest in Ehrlich’s ascites tumor cells implanted in mice.

Physicochemical Properties

M.Wt 338.247
Formula C12H17Cl2N3O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-((4-hydroxy-2-methylpyrimidin-5-yl)methyl)-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride hydrochloride

References

1. Thomas AA, et al. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2206-10.

2. Tseng CW, et al. Cancer Res. 2018 Mar 29. pii: canres.2906.2017.

3. Ricciardelli C, et al. Clin Exp Metastasis. 2015 Jun;32(5):441-55.

4. Raïs B, et al. FEBS Lett. 1999 Jul 30;456(1):113-8.

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